456 PREMATURE ADRENARCHE: CLINICAL AND DIAGNOSTIC FEATURES

Normal and Premature Adrenarche

Genetic Variation in Premature Adrenarche

Premature adrenarche (PA) is defined as adrenarcheal levels of adrenal androgens before the age of 8 yrs in girls and the age of 9 yrs in boys leading to androgenic signs ranging from pubarche to oily skin and adult type body odor. PA has been connected with adverse metabolic features and increased risk for ovarian hyperandrogenism. The pathogenesis of PA is considered polygenic. However, under...

Clinical Study LHDynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity

Background. Excess adiposity and premature adrenarche (PA) are risk factors for the development of polycystic ovary syndrome (PCOS). Methods. Girls with slowly progressive precocious breast development, who were overweight and had PA (SPPOPA, 6.2– 8.2 years, n = 5), overweight PA (6.6–10.8 years, n = 7), and overweight premenarcheal controls (OW-PUB, 10.6–12.8 years, n = 8) underwent hormonal s...

Neurobrucellosis: clinical and diagnostic features.

BACKGROUND We describe the neurological involvement in brucellosis and revisited diagnostic criteria for neurobrucellosis. METHODS Patients with laboratory-confirmed brucellosis who were consequently hospitalized were observed prospectively in a brucellosis-endemic region. The neurobrucellosis was diagnosed by any one of the following criteria: (1) symptoms and signs consistent with neurobruc...

Premature adrenarche--a common condition with variable presentation.

Adrenarche refers to a maturational increase in the secretion of adrenal androgen precursors, mainly dehydroepiandrosterone (DHEA) and its sulfate (DHEAS). In premature adrenarche (PA), clinical signs of androgen action appear before the age of 8/9 years in girls/boys, concurrently with the circulating DHEA(S) concentrations above the usually low prepubertal level. The most pronounced sign of P...